Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages

Neurodegenerative Disease & Movement Disorders A clinical perspective into early stages of neurodegenerative disease

Advances in therapeutical strategies for neurodegenerative diseases would reduce the burden related to these diseases. To test effectively compounds for diseases such as Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), or Alzheimer’s disease (AD) bring therapy to individuals as early as possible, there is an urgent need for the establishment of standards and networks for iden...

[The loss, the central symptom of depressive syndromes].

Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models

Late onset neurodegenerative diseases represent a major public health concern as the population in many countries ages. Both frequent diseases such as Alzheimer disease (AD, 14% incidence for 80-84 year-old Europeans) or Parkinson disease (PD, 1.4% prevalence for >55 years old) share, with other low-incidence neurodegenerative pathologies such as spinocerebellar ataxias (SCAs, 0.01% prevalence)...

Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer's Disease: Kuopio ALSOVA Study

BACKGROUND/AIM Alzheimer's disease (AD) causes impairment in memory and other cognitive functions as well as neuropsychiatric symptoms and limitations in the activities of daily living (ADL). The aim of this study was to examine whether demographic variables, dementia severity, ADL and neuropsychiatric symptoms are associated with cognition in very mild or mild AD. METHODS We analyzed the bas...

Depressive syndromes in dementia.

BACKGROUND Depressive syndromes in dementia are common, treatment is challenging and controlled intervention studies are small in number. The goal of this paper is to review known information about the etiology, epidemiology and treatment of these syndromes, as summarized at the recent Canadian Consensus Conference on Dementia. METHODS A number of Medline searches were performed (most recentl...